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Behavioral Predictors of Colonization withLactobacillus crispatusorLactobacillus jenseniiafter Treatment for Bacterial Vaginosis: A Cohort Study

Year: 2012

Type: article

Abstract: OBJECTIVE: Evaluate predictors of vaginal colonization with lactobacilli after treatment for bacterial vaginosis (BV). METHODS: Vaginal fluid specimens from women with BV underwent qPCR for Lactobacillus crispatus, L. jensenii, and L. iners pre- and posttreatment. RESULTS: Few women with BV were colonized with L. crispatus (4/44, 9%) or L. jensenii (1/44, 2%), though all had L. iners. One month posttreatment 12/44 (27%) had L. crispatus, 12/44 (27%) L. jensenii, and 43/44 (98%) L. iners. Presence of L. jensenii posttreatment was associated with cure (Risk Ratio (RR) 1.67; 95% CI 1.09-2.56); L. crispatus showed a similar trend (RR 1.41; 95% CI 0.89-2.24, P = 0.14). Receptive oral sex was associated with 2.2-log(10) lower concentration of L. crispatus (95% CI -4.38, -.02), and digital-vaginal sex with 2.6-log(10) lower concentration (95% CI -4.87, -.33). CONCLUSION: One month after BV treatment, few women established colonization with L. crispatus or L. jensenii. Few behaviors were associated with colonization.

Source: Infectious Diseases in Obstetrics and Gynecology

DOI: 10.1155/2012/706540

Authors: Caroline Mitchell, Lisa E. Manhart, Kathy Thomas, Tina Fiedler, David N. Fredricks, Jeanne Marrazzo

Institutions: University of Washington, Fred Hutch Cancer Center

Language: English

Topic: Reproductive tract infections research

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $820