Work

Changes in CSF and plasma HIV-1 RNA and cognition after starting potent antiretroviral therapy

Year: 2003

Type: article

Abstract: The authors assessed CSF and plasma HIV-1 RNA and neuropsychological test performance (composite neuropsychological test Z score [NPZ-4]) in 25 HIV-1-infected subjects 4 and 8 weeks after beginning potent antiretroviral therapy that included a protease inhibitor. In the 14 subjects who entered the study on no antiretroviral treatment, NPZ-4 improvement was associated with decline in CSF HIV-1 RNA at both visits (p = 0.001 and p = 0.02), and those treated with zidovudine or indinavir had greater improvement in NPZ-4 at both visits compared to those treated with other drugs (p = 0.003 and p = 0.01).

Source: Neurology

DOI: 10.1212/01.wnl.0000058768.73358.1a

Authors: C.M. Marra, D. Lockhart, J.R. Zunt, M. Perrin, R.W. Coombs, A.C. Collier

Institution: University of Washington

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of Mental Health, National Institute of Allergy and Infectious Diseases