Work

Sargramostim (GM-CSF) Combined with IV Plerixafor to Mobilize Peripheral Blood Stem Cells (PBSC) from Normal HLA-Matched Allogeneic Sibling Donors

Year: 2014

Type: article

Abstract: We have previously reported a lower than expected incidence of acute GVHD in recipients of sibling donor allogeneic HSC transplants mobilized with GM-CSF alone (Devine et al. BMT 2005). However, the use of GM-CSF as a single agent for stem cell mobilization has been limited by a high (∼30%) incidence of failure to mobilize and collect adequate stem cell numbers in a single apheresis procedure. Based on observed synergy between GM-CSF and plerixafor for HSC mobilization in mice, we hypothesized that this combination in humans might overcome the low stem cell yields observed with either agent alone and result in a PBSC product enriched in Tregs and MDSCs that could reduce GvHD after transplant.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2013.12.036