Work

Brain peptides and glial growth. II. Identification of cells that secrete glia-promoting factors.

Year: 1986

Type: article

Abstract: Glia-promoting factors (GPFs) are brain peptides which stimulate growth of specific macroglial populations in vitro. To identify the cellular sources of GPFs, we examined enriched brain cell cultures and cell lines derived from the nervous system for the production of growth factors. Ameboid microglia secreted astroglia-stimulating peptides, while growing neurons were the best source of the oligodendroglia-stimulating factors. These secretion products co-purified by gel filtration, anion exchange chromatography, and reverse-phase high performance liquid chromatography with GPFs isolated from goldfish and rat brain. Our findings suggest that glial growth in the central nervous system is regulated in part by a signaled release of peptides from specific secretory cells.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.102.3.812

Authors: D Giulian, D G Young

Institution: Baylor College of Medicine

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: March of Dimes Foundation, National Institutes of Health, National Eye Institute, National Institute of Neurological Disorders and Stroke