Work

Virus-induced differential expression of nuclear receptors and coregulators in dendritic cells: Implication to interferon production

Year: 2011

Type: article

Abstract: We investigated mRNA expression of 49 nuclear hormone receptors (NRs) and 35 transcriptional coregulators in mouse bone marrow-derived dendritic cells (DCs) upon infection with Newcastle Disease virus (NDV) or murine cytomegalovirus (MCMV). These viruses regulated mRNA expression of some NRs among which NOR1 and LXRα were highly induced at mRNA and protein levels. Exogenous expression of the latter NRs repressed IRF3- or IRF7-induced transactivation of the interferon β promoter and NDV infection further potentiated their repressive effect. The viral infection also significantly regulated mRNA expression of some coregulators, including HDAC1. Toll-like receptor ligands regulated NR and coregulator mRNA expression similar to the viruses. Thus, NRs and coregulators are integral components of DC-organizing anti-viral response wherein NOR1 and LXRα participate in regulating interferon production.

Source: FEBS Letters

DOI: 10.1016/j.febslet.2011.04.001

Authors: Sinnie Sin Man Ng, Tsung-Hsien Chang, Prafullakumar Tailor, Keiko Ozato, Tomoshige Kino

Institutions: National Institutes of Health, Chinese University of Hong Kong, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Language: English

Topic: interferon and immune responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development