Developmental regulatory bits
Year: 2008
Type: article
Abstract: This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution and reproduction in any medium, provided the original author and source are credited. Creation of derivative works is permitted but the resulting work may be distributed only under the same or similar licence to this one. This licence does not permit commercial exploitation without specific permission. Although the instances where substantive theory provides more than a metaphor for biology are rare, one fruitful approach has been computing physical limits on biological processes. In the best of cases, such as Berg and Purcell (1977), a simplified model of bacterial chemotaxis illuminated the problems bacteria have solved to operate at the limits imposed by molecular noise. In a recent article published in the Proceedings of the National Academy of Sciences, Tkačik et al (2008) borrow an approach from computational neuroscience (Laughlin, 1981) to show that the performance of the first step
Source: Molecular Systems Biology
DOI: 10.1038/msb.2008.64
Author: Eric D Siggia
Institution: Rockefeller University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $7,990
OpenAlex ID: W2076817084