Work

Antiinflammatory effects of apoptotic cells

Year: 2013

Type: article

Abstract: Apoptotic cells are rapidly phagocytosed by macrophages, a process that represents a critical step in tissue remodeling, immune responses, and the resolution of inflammation. In 1998, Peter Henson, Donna Bratton, and colleagues at National Jewish Health demonstrated that phagocytosis of apoptotic cells actively suppresses inflammation by inhibiting the production of inflammatory cytokines and inducing production of antiinflammatory factors, including TGF-β and prostaglandin E2. Here they discuss the evolving relationship among apoptosis, phagocytosis, and inflammation.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci69344

Authors: Peter M. Henson, Donna L. Bratton

Institution: National Jewish Health

Language: English

Topic: Phagocytosis and Immune Regulation

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: U.S. Public Health Service, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases