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Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: Evidence for genomic instability

Year: 2011

Type: article

Abstract: Secondary malignancies (SMs) in Hodgkin lymphoma (HL) are thought to be related to exposure to alkalating agents, topoisomerase II inhibitors and ionizing radiation, and tend to occur a decade after initial therapy. We report a 14 year old autistic male, who developed malignant fibrous histiocytoma (MFH) two years after autologous stem cell transplantation for advanced stage HL. The MFH and post-surgical reactive tissues exhibited multiple clonal abnormalities. In addition, PHA-stimulated peripheral blood lymphocytes showed increased frequency of non-clonal chromosomal aberrations. The potential role of genomic instability in early onset of SM in our patient is discussed.

Source: Pediatric Blood & Cancer

DOI: 10.1002/pbc.22929

Authors: Shanmuganathan Chandrakasan, Christine J. Ye, Meera Chitlur, Anwar N. Mohamed, Raja Rabah, Andre Konski, Henry H. Q. Heng, Süreyya Savaşan

Institutions: Wayne State University, Children's Hospital of Michigan, The Barbara Ann Karmanos Cancer Institute

Language: English

Topic: Multiple and Secondary Primary Cancers

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2077357367

FWCI: 1.2

Cites: 22

Cited by: 21

Related to: 10