Work

Clinical Translation of Cell-Based Pharmacogenomic Discovery

Year: 2012

Type: article

Abstract: The use of cell-based models has emerged as a promising means to discover and validate pharmacologic phenotype-genotype relationships. The availability of large-scale genome studies in both human and model systems is now allowing us an unprecedented opportunity to understand how well cell-based models identify clinically relevant genetic variants associated with drug response and toxicity. Here we review these studies and the emerging translational information.

Source: Clinical Pharmacology & Therapeutics

DOI: 10.1038/clpt.2012.115

Authors: N J Cox, E R Gamazon, H E Wheeler, M E Dolan

Institution: University of Chicago

Language: English

Topic: Pharmacogenetics and Drug Metabolism

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Cancer Institute, National Institute of General Medical Sciences