Work

Scheme for efficient fiber-based CARS probe

Year: 2010

Type: conference-paper

Abstract: We demonstrate a fiber-based probe for maximum collection of the Coherent anti-Stokes Raman Scattering (CARS) signal in biological tissues. We discuss the design challenges including capturing the back-scattered forward generated CARS signal in the sample and the effects of fiber nonlinearities on the propagating pulses. Three different biological tissues were imaged in vitro in order to assess the performance of our fiberdelivered probe for CARS imaging, a tool which we consider an important advance towards label-free, in vivo probing of superficial tissues.

Source: Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI: 10.1117/12.855187

Authors: Mihaela Balu, Gangjun Liu, Zhongping Chen, Bruce J. Tromberg, Eric O. Potma

Institutions: Beckman Laser Institute and Medical Clinic, University of California, Irvine

Language: English

Topic: Spectroscopy Techniques in Biomedical and Chemical Research

Subfield: Biophysics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Science Foundation, National Institutes of Health, National Institute of Biomedical Imaging and Bioengineering, Air Force Office of Scientific Research