Work

Overcoming obstacles to the effective immunotherapy of human cancer

Year: 2008

Type: article

Abstract: Cancers can grow and spread in humans despite their expression of cancer-associated antigens and the presence, within the tumor, of immune lymphocytes that can recognize those antigens. One of the possible explanations for this paradox is discussed in the article by Bai et al. (1) in this issue of PNAS. They demonstrate that anti-tumor T cells can be tolerized in the tumor microenvironment and thus down-regulate their effector functions. This is but one element in a complex story.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.0806877105

Author: Steven A. Rosenberg

Institution: National Cancer Institute

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2077892236

FWCI: 2.644

Cites: 20

Cited by: 52

Related to: 10