Year: 2014
Type: article
Abstract: A method for selectively inducing apoptosis in tumor nodules is presented, with close-to-cellular level resolution, using 3D-resolved widefield temporal focusing illumination. Treatment times on the order of seconds were achieved using Verteporfin as the photosensitizer, with doses of 30 μ g ml −1 and below. Results were achieved on both 2D and 3D cell cultures, demonstrating that treatment was possible through approximately one hundred microns of dense tumor nodules.
Source: Laser Physics Letters
Authors: Christopher J Rowlands, Jackie Wu, Sebastien G M Uzel, Oliver Klein, Conor L Evans, Peter T C So
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,325
Funders: National Science Foundation, Emergent Behaviors of Integrated Cellular Systems, Wellcome Trust, Skolkovo Institute of Science and Technology, National Institutes of Health, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering, Division of Chemical, Bioengineering, Environmental, and Transport Systems
Awards: G1811142779, G2432239036, A Versatile, Minimally-Invasive Treatment for Cancer: Applying Temporal Focusing to Photodynamic Therapy., G270120649, G281903038, Imaging and Overcoming Hypoxia-Induced Resistance in Metastatic Ovarian Cancer, G4035684527, G4113606792, G4473449232, NSF Science and Technology Center: Emergent Behaviors of Integrated Cellular Systems, Regenerative Healing Using ECM Based Scaffolds, MIT Laser Biomedical Research Center, High Throughput Manufacturing for Three-Dimensional Microfluidic Devices, A Versatile, Minimally-Invasive Treatment for Cancer: Applying Temporal Focusing to Photodynamic Therapy.
OpenAlex ID: W2077994313