Work

Molecular genetics of timing in intrinsic circadian rhythm sleep disorders

Year: 2002

Type: article

Abstract: Recent advances in circadian biology are identifying key genes and the molecular clockworks they command. These biochemical systems provide new tools for evaluating clinically observed, intrinsic circadian rhythm sleep disorders. A striking example was last year's discovery of a point mutation in a human clock gene that produces a sleep phase syndrome. This finding suggested that other intrinsic sleep disorders may have genetic underpinnings, and that less debilitating variations in sleep/wake behavior may be revealed by molecular screening of known clock genes in broader human populations.

Source: Annals of Medicine

DOI: 10.1080/078538902320772133

Authors: Herman Wijnen, Catharine Boothroyd, Michael W Young, Adam Claridge-Chang

Institution: Rockefeller University

Language: English

Topic: Circadian rhythm and melatonin

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institute of Mental Health, National Institute of General Medical Sciences