Work

Genome-wide prediction of transcription factor binding sites using an integrated model

Year: 2010

Type: article

Abstract: We present an integrated method called Chromia for the genome-wide identification of functional target loci of transcription factors. Designed to capture the characteristic patterns of transcription factor binding motif occurrences and the histone profiles associated with regulatory elements such as promoters and enhancers, Chromia significantly outperforms other methods in the identification of 13 transcription factor binding sites in mouse embryonic stem cells, evaluated by both binding (ChIP-seq) and functional (RNA interference knockdown) experiments.

Source: Genome biology

DOI: 10.1186/gb-2010-11-1-r7

Authors: Kyoung-Jae Won, Bing Ren, Wei Wang

Institutions: University of California San Diego, Ludwig Cancer Research, Ludwig Cancer Research

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $5,490

Funders: National Institutes of Health, National Institute of General Medical Sciences