Work

Distinct type‐2A protein phosphatases activate HMGCoA reductase and acetyl‐CoA carboxylase in liver

Year: 1997

Type: article

Abstract: Acetyl-CoA carboxylase and HMGCoA reductase are inactivated by the same AMP-activated protein kinase and are activated by type-2A protein phosphatase. To determine whether the same species of protein phosphatase-2A were involved, we studied the interconversion of acetyl-CoA carboxylase and HMGCoA reductase in isolated rat hepatocytes. We show that (i) these enzymes are differently regulated in hepatocytes and (ii) the species of type-2A protein phosphatase involved in their activation are different and can be separated by anion-exchange chromatography.

Source: FEBS Letters

DOI: 10.1016/s0014-5793(97)00890-9

Authors: Vinciane Gaussin, Polymnia Skarlas, Yick Pang Ching, D.Grahame Hardie, Louis Hue

Institutions: UCLouvain, University of Dundee

Language: English

Topic: Metabolism, Diabetes, and Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,980

Funders: Wellcome Trust, Fédération Wallonie-Bruxelles