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Transformation of the proteasome with age‐related macular degeneration

Year: 2007
Type: article
Abstract: The proteasome mediates pathways associated with oxidative stress and inflammation, two pathogenic events correlated with age-related macular degeneration (AMD). In human donor eyes corresponding to four stages of AMD, we found the proteasomal chymotrypsin-like activity increased in neurosensory retina with disease progression. Increased activity correlated with a dramatic increase in the inducible subunits of the immunoproteasome, which was not due to an increase in CD45 positive immune cells in the retina. The novel observation of proteasome transformation may reflect retinal response to local inflammation or oxidative stress with AMD.
Source: FEBS Letters
DOI: 10.1016/j.febslet.2007.01.061
Authors: Cheryl M. Ethen, Stacy A. Hussong, Cavan Reilly, Xiao Feng, Timothy W. Olsen, Deborah A. Ferrington
Language: English
Open Access status: bronze
Funders: American Federation for Aging Research, American Health Assistance Foundation, Minnesota Lions Eye Bank, Research to Prevent Blindness, University of Minnesota, National Institutes of Health, National Institute on Aging, National Eye Institute
Awards: G1312753319, G1601830638, G1896660322, G2009394503, Visual Neuroscience Training Program, Proteomics of altered protein in macular degeneration, Proteasome Function in the Aging Retina, The Subproteome in Age-related Macular Degeneration
OpenAlex ID: W2078114300
FWCI: 2.382
Cites: 31
Cited by: 77
Related to: 10