Work

Influence of activating Fcgamma receptors on osteoclast differentiation and bone metabolism

Year: 2012

Type: article

Abstract: Background Patients with Rheumatoid Arthritis suffering from chronic inflammation of the joints have a higher risk of developing osteoporosis. One hallmark of this inflammatory process is an increased production of autoantibodies. It is unclear, whether the autoantibodies can act directly on cells of the bone metabolism via Fcgamma receptors (FcgRs). Thus, the aim of this project is to analyze the influence of the activating FcgR expression on osteoclasts, the bone-resorbing cells, and the bone metabolism in vitro and in vivo by comparison of C57Bl/6 and several FcgR knockout mice.

Source: Journal of Translational Medicine

DOI: 10.1186/1479-5876-10-s3-p24

Authors: Michaela Seeling, Jan Peter Tuckermann, Jean Pierre David, Georg Schett, Falk Nimmerjahn

Institutions: Friedrich-Alexander-Universität Erlangen-Nürnberg, Universität Ulm, University Medical Center Hamburg-Eppendorf

Language: English

Topic: Bone Metabolism and Diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,890