Work

Regulation of T‐cell receptor signaling by the actin cytoskeleton and poroelastic cytoplasm

Year: 2013

Type: review

Abstract: The actin cytoskeleton plays essential roles in modulating T-cell activation. Most models of T-cell receptor (TCR) triggering signalosome assembly and immune synapse formation invoke actin-dependent mechanisms. As T cells are constitutively motile cells, TCR triggering and signaling occur against a cytoskeletal backdrop that is constantly remodeling. While the interplay between actin dynamics and TCR signaling have been the focus of research for many years, much of the work in T cells has considered actin largely for its 'scaffolding' function. We examine the roles of the actin cytoskeleton in TCR signaling and immune synapse formation with an emphasis on how poroelasticity, an ensemble feature of actin dynamics with the cytosol, relates to how T cells respond to stimulation.

Source: Immunological Reviews

DOI: 10.1111/imr.12120

Authors: Peter Beemiller, Matthew F. Krummel

Institution: University of California, San Francisco

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: Molecular and Cellular Immunology, Spatiotemporal Control of T cell Synapse Stabilization and Signaling, Evolving Microenvironments in Airway Inflammation, Diabetes Research Center