Work

Development of biomarkers of human exposure to carcinogens: the example of DNA-protein cross-links

Year: 1995

Type: article

Abstract: Biomarkers are considered to be more biologically informative than traditional methods and less prone to misclassification bias. However, new biomarkers are conceived in experimental laboratories and normally undergo extensive experimental in vitro and in vivo testing, usually without regard as to their potential use in humans. Whereas the epidemiologist had no role in the original development of the basic research idea leading to the initial formulation of a biomarker, the new biomarker or technical modification of an existing one are the product of observations in humans. The results of our field studies on DNA-protein cross-links (DPX) among chromate workers illustrates inherent difficulties in the process of development and validation of biomarkers.

Source: Toxicology Letters

DOI: 10.1016/s0378-4274(97)84689-9

Authors: Paolo Toniolo, Emanuela Taioli

Institution: New York University

Language: English

Topic: Carcinogens and Genotoxicity Assessment

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,270