Work

Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample

Year: 2008

Type: article

Study design: Observational Study

Abstract: The dyslexia susceptibility locus DYX2 (chr. 6p21-p22) harbours two candidate genes, DCDC2 and KIAA0319. In 2006, Harold et al. reported evidence for interaction between both genes. Having previously identified a risk haplotype for dyslexia in DCDC2, but not KIAA0319, in German families, we also tested for interaction between this risk haplotype and KIAA0319. We found a nominally significant association for the quantitative dimension "word reading", the core phenotype in the study of Harold et al., which may be considered as supportive evidence.

Source: Journal of Neural Transmission

DOI: 10.1007/s00702-008-0124-6

Authors: Kerstin U. Ludwig, Darina Roeske, Johannes Schumacher, Gerd Schulte-Körne, Inke R. König, Andreas Warnke, Ellen Plume, Andreas Ziegler, Helmut Remschmidt, Bertram Müller-Myhsok, Markus M. Nöthen, Per Hoffmann

Institutions: University of Bonn, Max Planck Institute of Psychiatry, LMU Klinikum, Ludwig-Maximilians-Universität München, University Hospital Schleswig-Holstein, University of Lübeck, University of Würzburg, Philipps University of Marburg

Language: English

Topic: Reading and Literacy Development

Subfield: Developmental and Educational Psychology

Field: Psychology

Domain: Social Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,690

Funders: Deutsche Forschungsgemeinschaft, Alfried Krupp von Bohlen und Halbach-Stiftung

OpenAlex ID: W2078622002

FWCI: 7.029

Cites: 16

Cited by: 41

Related to: 10