Work

68 Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers

Year: 2014

Type: article

Abstract: We have developed a (68)Ga metal chelating bioorthogonal tetrazine dextran probe that is highly reactive with trans-cyclooctene modified monoclonal antibodies for multistep imaging applications. Confocal microscopy and positron emission tomography (PET) were used to characterize the dextran probe in vitro and in vivo.

Source: Chemical Communications

DOI: 10.1039/c3cc49530b

Authors: Brandon Nichols, Zhengtao Qin, Jun Yang, David R. Vera, Neal K. Devaraj

Institutions: University of California System, University of California San Diego

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering

Awards: G1323291101, Fast in vivo CLICK chemistries for PET imaging