Work

Bromophycolide A Targets Heme Crystallization in the Human Malaria Parasite Plasmodium falciparum

Year: 2011

Type: article

Abstract: A heme run: A combination of synthetic and isolation studies allowed detailed mapping of the antiplasmodial structure–activity relationships of a unique class of macrocyclic meroditerpenes from the red macroalga Callophycus serratus. This SAR map was used to develop fluorescent probes that identified heme crystallization within neutral lipid nanospheres as a mode of action of bromophycolide A.

Source: ChemMedChem

DOI: 10.1002/cmdc.201100252

Authors: E. Paige Stout, Serena Cervantes, Jacques Prudhomme, Stefan France, James J. La Clair, Karine Le Roch, Julia Kubanek

Institutions: Georgia Institute of Technology, University of California, Riverside, Xenobe Research Institute

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, Fogarty International Center

Awards: Exploration, conservation, & development of marine biodiversity in Fiji and the S, Exploration, conservation, & development of marine biodiversity in Fiji

OpenAlex ID: W2078857870

FWCI: 1.884

Cites: 38

Cited by: 21

Related to: 10