Work

Dectin-1 Fc Targeting of Aspergillus fumigatus Beta-Glucans Augments Innate Defense against Invasive Pulmonary Aspergillosis

Year: 2007

Type: article

Abstract: Invasive pulmonary aspergillosis (IPA) has significantly increased over the last decade. Here, a fusion protein consisting of the Dectin-1 extracellular domain linked to the Fc portion of murine immunoglobulin G1 augmented alveolar macrophage killing of Aspergillus fumigatus and shifted mortality associated with IPA via attenuation of A. fumigatus growth in the lung.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01274-07

Authors: Polly E. Mattila, Allison E. Metz, Rekha R. Rapaka, Lynne D. Bauer, Chad Steele

Institutions: University of Pittsburgh, University of Alabama at Birmingham

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Heart, Lung, and Blood Institute