Work

Patterning of frontal cortex subdivisions by Fgf17

Year: 2007

Type: article

Abstract: The frontal cortex (FC) is the seat of higher cognition. The genetic mechanisms that control formation of the functionally distinct subdivisions of the FC are unknown. Using a set of gene expression markers that distinguish subdivisions of the newborn mouse FC, we show that loss of Fgf17 selectively reduces the size of the dorsal FC whereas ventral/orbital FC appears normal. These changes are complemented by a rostral shift of sensory cortical areas. Thus, Fgf17 functions similar to Fgf8 in patterning the overall neocortical map but has a more selective role in regulating the properties of the dorsal but not ventral FC.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.0702225104

Authors: Jeremy A. Cholfin, John L. R. Rubenstein

Institution: University of California, San Francisco

Language: English

Topic: Neurogenesis and neuroplasticity mechanisms

Subfield: Developmental Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

Funders: National Institute of Mental Health, National Institute of Neurological Disorders and Stroke

Awards: Genetic Regulation of Telencephalon Development, Genetic Studies of Cortex Structure and Development, G6084662103