Work

Nitration inhibits fibrillation of human α‐synuclein in vitro by formation of soluble oligomers

Year: 2003

Type: article

Abstract: The aggregation of alpha-synuclein in dopaminergic neurons is a critical factor in the etiology of Parkinson's disease (PD). Oxidative and nitrative stress is also implicated in PD. We examined the effect of nitration on the propensity of alpha-synuclein to fibrillate in vitro. Fibril formation of alpha-synuclein was completely inhibited by nitration, due to the formation of stable soluble oligomers (apparently octamers). More importantly the presence of sub-stoichiometric concentrations of nitrated alpha-synuclein led to inhibition of fibrillation of non-modified alpha-synuclein. These observations suggest that nitration of soluble alpha-synuclein may be a protective factor in PD, rather than a causative one.

Source: FEBS Letters

DOI: 10.1016/s0014-5793(03)00367-3

Authors: Ghiam Yamin, Vladimir N Uversky, Anthony L Fink

Institutions: University of California, Santa Cruz, Russian Academy of Sciences, Institute for Biological Instrumentation

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Institute of Neurological Disorders and Stroke