Increased Program Cell Death–1 Expression on T Lymphocytes of Patients With Progressive Multifocal Leukoencephalopathy
Year: 2012
Type: article
Study design: Observational Study
Abstract: The cellullar immune response is important in the containment of progressive multifocal leukoencephalopathy (PML). We examined program cell death-1 (PD-1) expression, a marker of cellular immune exhaustion, on T lymphocytes in PML. PD-1 expression was elevated on total CD4(+) and CD8(+) T cells (medians 36% and 24%) in PML patients compared with healthy control subjects (medians 14% and 18%; P = 0.0015 and P = 0.033). In PML patients, JC virus (JCV)-specific CD8(+) cytotoxic T lymphocytes expressed PD-1 more frequently than total CD8 T lymphocytes (means 39% and 78%, P = 0.0004). Blocking the PD-1 receptor increased JCV-specific T-cell immune response in a subgroup of PML patients.
Institutions: Beth Israel Deaconess Medical Center, Harvard University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1492917168, Harvard Clinical and Translational Science Center (UL1), Host-tumor cell interaction in myeloma: therapeutic applications, Cellular Immunity to JC Virus in AIDS-Associated Progressive Multifocal Leukoence, G4680808690, G480561736, SPORE in Multiple Myeloma, Molecular Sequelae of Myeloma-Bone Marrow Interactions: Therapeutic Applications, Cellular Immunity/JC Virus/AIDS/Leukoencephalopathy, Role of Inflammation in Progressive Multifocal Leukoencephalopathy, Translational applications of Progressive Multifocal Leukoencephalopathy studies, Integrative Oncogenomics of Multiple Myeloma, Multidisciplinary HIV Training Program, Infectious Disease and Basic Microbiological Mechanisms, JC Virus Primary Infection, Latency, and Reactivation
OpenAlex ID: W2079163635