Atg9 cycling: The molecular mechanisms of anterograde and retrograde Atg9 trafficking
Year: 2011
Type: dissertation
Abstract: Autophagy is a cellular catabolic pathway and plays an important role in various diseases such as\ncancer and neurodegeneration. In autophagy, there is the formation of an double-membrane vesicle\ncalled the autophagosome. The only currently known protein responsible for membrane delivery to\nthe phagophore assembly site, where the autophagosome is formed, is Atg9. Atg9 cycles between its\nreservoirs and the PAS, but the mechanisms of this cycling are poorly understood. Here, I discuss\nwhat is currently known about the anterograde and retrograde of Atg9 trafficking in yeast and\ncompare it with trafficking in mammalian cells. Finally, I show a few experiments which provide data\non Atg18, one of the proteins involved in the retrograde transport of Atg9.
Author: A.W. van der Burgh
Language: English
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W207963383