Work

Magnetomotive contrast for in vivo optical coherence tomography

Year: 2005

Type: article

Abstract: Molecularly-specific contrast can greatly enhance the biomedical utility of optical coherence tomography (OCT). We describe a contrast mechanism, magnetomotive OCT (MMOCT), where a modulated magnetic field induces motion of magnetic nanoparticles. The motion of the nanoparticles modifies the amplitude of the OCT interferogram. High specificity is achieved by subtracting the background fluctuations of the specimen, and sensitivity to 220 microg/g magnetite nanoparticles is demonstrated. Optically and mechanically correct tissue phantoms elucidate the relationships between imaging contrast and nanoparticle concentration, imaging depth, tissue optical scattering, and magnetic field strength. MMOCT is demonstrated in a living Xenopus laevis tadpole where the results were consistent with corresponding histology.

Source: Optics Express

DOI: 10.1364/opex.13.006597

Authors: Amy L. Oldenburg, Farah Jean-Jacques Toublan, Kenneth S. Suslick, Alexander Wei, Stephen A. Boppart

Institutions: University of Illinois Urbana-Champaign, Purdue University West Lafayette

Language: English

Topic: Optical Coherence Tomography Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,270