Validation of DTI Tractography-Based Measures of Primary Motor Area Connectivity in the Squirrel Monkey Brain
Year: 2013
Type: article
Abstract: Diffusion tensor imaging (DTI) tractography provides noninvasive measures of structural cortico-cortical connectivity of the brain. However, the agreement between DTI-tractography-based measures and histological 'ground truth' has not been quantified. In this study, we reconstructed the 3D density distribution maps (DDM) of fibers labeled with an anatomical tracer, biotinylated dextran amine (BDA), as well as DTI tractography-derived streamlines connecting the primary motor (M1) cortex to other cortical regions in the squirrel monkey brain. We evaluated the agreement in M1-cortical connectivity between the fibers labeled in the brain tissue and DTI streamlines on a regional and voxel-by-voxel basis. We found that DTI tractography is capable of providing inter-regional connectivity comparable to the neuroanatomical connectivity, but is less reliable measuring voxel-to-voxel variations within regions.
Source: PLoS ONE
Authors: Yurui Gao, Ann S. Choe, Iwona Stepniewska, Xia Li, Malcolm J. Avison, Adam W. Anderson
Institution: Vanderbilt University
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,382
Funders: Vanderbilt University, Vanderbilt University Medical Center, National Institutes of Health, National Institute on Drug Abuse, National Eye Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Center for Research Resources, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1149166549, Eunice Kennedy Shriver Intellectual and Developmental Disability Research Center, G150953014, G2133419871, G2940777275, G3003698295, G3166704001, G3416501184, G35732448, G3722609264, G3865556588, G3989539122, Vanderbilt Mouse Metabolic Phenotyping Center, G4320917349, G4416941928, G4513176822, G5132347646, G5853943267, The Biological Basis of Diffusion MRI of the Brain, G6297262231, G6520332466, G7220527126, High Resolution MRI Mapping of CNS Plasticity, G8391480415, G8410895666, G9000002043, G9000060478, G9000081609, G9000106052, G9000135199, G9000159340, Molecular and Cellular Basis for Digestive Diseases, Cancer Center Support Grant, Vanderbilt Diabetes Research Center, Core Grant in Vision Research
OpenAlex ID: W2079795772