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HLA-E–dependent Presentation of Mtb-derived Antigen to Human CD8+ T Cells

Year: 2002
Type: article
Abstract: Previous studies in mice and humans have suggested an important role for CD8+ T cells in host defense to Mtb. Recently, we have described human, Mtb-specific CD8+ cells that are neither HLA-A, B, or C nor group 1 CD1 restricted, and have found that these cells comprise the dominant CD8+ T cell response in latently infected individuals. In this report, three independent methods are used to demonstrate the ability of these cells to recognize Mtb-derived antigen in the context of the monomorphic HLA-E molecule. This is the first demonstration of the ability of HLA-E to present pathogen-derived antigen. Further definition of the HLA-E specific response may aid development of an effective vaccine against tuberculosis.
DOI: 10.1084/jem.20020609
Authors: Amy S. Heinzel, Jeff E. Grotzke, Rebecca A. Lines, Deborah A. Lewinsohn, Andria L. McNabb, Daniel N. Streblow, Veronique M. Braud, Heather J. Grieser, John T. Belisle, David M. Lewinsohn
Language: English
Field: Medicine
Open Access status: bronze
Awards: TUBERCULOSIS RESEARCH MATERIALS AND VACINE TESTING, Recognition of Mtb-infected cells by CD8+ T lymphocytes, G60310657, HUMAN T CELL RESPONES TO MYCOBACTERIUM TUBERCULOSIS, G6486901815, G9000005680, G9000151886
OpenAlex ID: W2079808029
FWCI: 6.53
Cites: 40
Cited by: 214
Related to: 8