Work

Effects of Dopamine in Man: Augmentation of Sodium Excretion, Glomerular Filtration Rate, and Renal Plasma Flow*

Year: 1964

Type: article

Abstract: Dopamine (3,4-dihydroxyphenylethylamine) is considered to be the immediate metabolic precur-sor of norepinephrine (1), from which it differs by the absence of a P-OH group. Despite this chemical similarity, previous studies of the action of dopamine (2-9) have demonstrated that many of the circulatory and metabolic effects of this catecholamine are different from those produced by norepinephrine. Horwitz, Fox, and Goldberg (6) observed that intravenous administration of dopamine to normal subjects produced consistent increases in cardiac output and either decreased or did not change peripheral resistance. Norepineph-rine, on the other hand, decreases or does not change cardiac output and increases peripheral resistance in normal subjects (10). The circu-latory effects of dopamine are potentiated by monoamine oxidase inhibitors to a much greater extent than are those of norepinephrine (9). Dopamine also contrasts with norepinephrine in its failure to increase circulating free fatty acids (7, 8). These differences suggest that the effects of * Submitted for publication July 12, 1963; accepted

Source: Journal of Clinical Investigation

DOI: 10.1172/jci104996

Authors: Robert H. McDonald, Leon I. Goldberg, John L. McNay, Elbert P. Tuttle

Institution: Emory University

Language: English

Topic: Blood Pressure and Hypertension Studies

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Emory University, School of Medicine, Emory University