Work

pH-Responsive Polymer Microspheres: Rapid Release of Encapsulated Material within the Range of Intracellular pH

Year: 2001

Type: article

Abstract: Microspheres formed from a new poly(β-amino ester) degrade slowly at pH 7.4 (left fluorescence microscopy image) but dissolve quickly at pH values below 6.5 (right), to release encapsulated material rapidly and quantitatively. As the pH/solubility transition occurs within the intracellular pH range, these tiny spheres hold promise as intracellular drug delivery vehicles.

Source: Angewandte Chemie International Edition

DOI: 10.1002/1521-3773(20010504)40:9<1707::aid-anie17070>3.0.co;2-f

Authors: David M. Lynn, Mansoor M. Amiji, Robert Langer

Institutions: Massachusetts Institute of Technology, Northeastern University

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: bronze

Funders: National Science Foundation, National Institutes of Health

Awards: Biotechnology Process Engineering Research Center, G9000190065