Work

Clinical Use of Interferon‐γ

Year: 2009

Type: review

Abstract: Interferon gamma (IFN-gamma), a pleotropic cytokine, has been shown to be important to the function of virtually all immune cells and both innate and adaptive immune responses. In 1986, early clinical trials of this cytokine began to evaluate its therapeutic potential. The initial studies focused on the tolerability and pharmacology of IFN-gamma and systematically determined its antitumor and anti-infection activities. In the 20-plus years since those first trials, IFN-gamma has been used in a wide variety of clinical indications, which are reviewed in this article.

Source: Annals of the New York Academy of Sciences

DOI: 10.1111/j.1749-6632.2009.05069.x

Authors: Catriona H.T. Miller, Stephen G. Maher, Howard A. Young

Institutions: Frederick National Laboratory for Cancer Research, National Cancer Institute, Center for Cancer Research, Trinity College Dublin, St. James's Hospital

Language: English

Topic: interferon and immune responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute