Synthesis of N-{4-[(2,4-Diamino-5-methyl-4,7-dihydro-3H- pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}- l -glutamic Acid and N-{4-[(2-Amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin- 6-yl)thio]benzoyl}- l -glutamic Acid as Dual Inhibitors of Dihydrofolate Reductase and Thymidylate Synthase and as Potential Antitumor Agents
Year: 2005
Type: article
Source: Journal of Medicinal Chemistry
DOI: 10.1021/jm058234m
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: closed
Awards: FOLYLPOLYGLUTAMATE SYNTHETASE IN CANCER CHEMOTHERAPY, FOLATE ENZYMES, COENZYMES AND ANTIMETABOLITES, ANALOGUES AND HOMOLOGUES OF TRIMETHOPRIM AND EPIROPRIM, STRUCTURE BASED ANALOGS AS ANTIOPPORTUNISTIC AGENTS, NOVEL NONINDUCIBLE THYMIDYLATE SYNTHASE INHIBITORS, Roswell Park Cancer Center Support Grant
OpenAlex ID: W2080098763
