Work

Highly diastereoselective synthesis of modified nucleosides via an asymmetric multicomponent reaction

Year: 2010

Type: article

Abstract: We have developed a practical synthesis of unique nucleoside derivatives via TiCl(4) promoted multicomponent reaction of optically active dihydrofuran, ethyl pyruvate/glyoxylate, and a TMS protected nucleobase in a single-pot operation.

Source: Chemical Communications

DOI: 10.1039/b924807b

Authors: Arun K. Ghosh, Jorden Kass

Institution: Purdue University West Lafayette

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: G5103706978, DESIGN AND SYNTHESIS OF NONPEPTIDE PROTEASE INHIBITORS, Design & Synthesis of Nonpeptide Protease Inhibitors

OpenAlex ID: W2080134720

FWCI: 1.267

Cites: 21

Cited by: 16

Related to: 10