176Time-temperature study of cell survival in Bone Marrow (BM) and Blood hematopoietic Progenitor Cell (HPC) grafts
Year: 2003
Type: article
Abstract: Poster Presentations -Session IIadverse events.Main Results: The number of CD34+ cells in the leukapheresis products were similar in the two groups: the geometric mean number of CD34+ cells was 1.73 x 10^6/kg in the once-daily group and 2.08 x 10^6/kg in the divided-dose group (P=.0.37).The geometric mean number of TNCs in the products was 6.43 x 10^8/kg in the once-daily group and 6.35 x 10A8/kg in the twice-daily group (P=0.87).Although the median total doses of analgesic drug were similar in both groups (6.35mg/kg vs 7.69mg/kg acetoaminophen, P=0.79), the donors in the once-dally group experienced significantly less pain than twice-daily group (median AUS of VAS; 21.5 vs 52.5 ram*days, P=0.043).The incidences and severities of adverse events other than pain were similar in both groups.Conclusions: In comparison with two-divided dose regimen, once daily injection of 400btg/m^2 of G-CSF is equally effective for allogeneic PBSC nmbilization and associated with less pain.Taldng into account of donor's convenience, oncedaily regimen is preferable to twice-daily regimen.
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2080226586