Work

RAP1‐like binding activity in islet cells corresponds to members of the Sp1 family of transcription factors

Year: 1997

Type: article

Abstract: Deletion and mutational analyses of the gastrin promoter have identified a binding site for the yeast transcription factor RAP1 relevant for transcriptional activation in islet cells. We here report that the mammalian transcription factors binding to this site in islet cells are the Sp transcription factor members Sp1 and Sp3. Furthermore, functional analyses revealed Sp1- and Sp3-mediated transcriptional activation of gastrin. These data reveal that the zinc finger proteins Sp1 and Sp3 do have similar binding specificities as the multifunctional yeast RAP1 protein.

Source: FEBS Letters

DOI: 10.1016/s0014-5793(97)00736-9