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Inherited genetic variation and overall survival following follicular lymphoma

Year: 2012
Type: article
Study design: Observational Study
Abstract: Follicular lymphoma (FL) has variable progression and survival, and improved identification of patients at high risk for progression would aid in identifying patients most likely to benefit from alternative therapy.In a sample of 244 FL cases identified during a population-based case-control study of non-Hodgkin lymphoma (NHL), we examined 6,679 tag SNPs in 488 gene regions for associations with overall FL survival. Over a median follow-up of 89 months with 65 deaths in this preliminary study, we identified 5 gene regions (BMP7, GALNT12,DUSP2, GADD45B, and ADAM17) that were associated with overall survival from FL. Results did not meet the criteria for statistical significance after adjustment for multiple hypothesis testing. These results,which support a role for host factors in determining the variable progression of FL, serve as an initial examination that can inform future studies of genetic variation and FL survival. However, they require replication in independent populations, as well as assessment in rituximab-treated patients.
DOI: 10.1002/ajh.23184
Authors: Todd M. Gibson, Sophia S. Wang, James R. Cerhan, Matthew J. Maurer, Patricia Hartge, Thomas M. Habermann, Scott Davis, Wendy Cozen, Charles F. Lynch, Richard K. Severson, Nathaniel Rothman, Stephen J. Chanock, Lindsay M. Morton
Institutions: National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, City Of Hope National Medical Center, City of Hope, Beckman Research Institute, Mayo Clinic, University of Washington, Fred Hutch Cancer Center, University of Southern California, University of Iowa, Wayne State University, The Barbara Ann Karmanos Cancer Institute
Language: English
Field: Medicine
Open Access status: bronze
Funders: U.S. Department of Health and Human Services, University of Southern California, Wayne State University, University of Washington, Beckman Research Institute, City of Hope, Barbara Ann Karmanos Cancer Institute, National Institutes of Health, National Cancer Institute
Awards: SURVEILLANCE EPIDEMIOLOGY &END RESULTS PROGRAM, G1041864957, G1220193100, SURVEILLANCE EPIDEMIOLOGY &END RESULTS PROGRAM, G1788914148, SURVEILLANCE, EPIDEMIOLOGY, AND END RESULTS--SEER, SURVEILLANCE EPIDEMIOLOGY &END RESULTS PROGRAM, G2755035673, G420411562, Immunogenetics of Non-Hodgkin Lymphoma Survival, G4836174358, G490749545, G5185757912, G5372537626, G6374948078, G7752797991, G835684289, G9000077506, Cancer Center Support Grant
OpenAlex ID: W2080330850
FWCI: 0.83
Cites: 31
Cited by: 15
Related to: 10