MiRNAs as Biomarkers for Management of Patients With Colorectal Cancer
Year: 2010
Type: review
Abstract: miRNAs serve as micromanagers, negatively regulating gene expression. Since altered miRNA expression is implicated in the pathobiology of various cancers, including colorectal cancers (CRCs), these molecules serve as potential therapeutic targets. Manipulation of miRNAs may offer an alternative therapy for chemo- and radio-resistant CRCs. For CRC patients, miRNA expression patterns can be used for diagnosis, and to predict prognosis and efficacy of therapy. This article describes the methodological approaches for miRNA measurement, their function in the pathobiology of CRCs and their potential clinical utility.
Source: Biomarkers in Medicine
DOI: 10.2217/bmm.10.87
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: green
Awards: CENTER FOR BIOMEDICAL RESEARCH, Predictive Molecular Markers of Colorectal Cancer, Prognostic Molecular Markers of Colorectal Cancer, 2/3 Morehouse School of Medicine/Tuskegee University/ University of Alabama at Birmingham O'Neal Comprehensive Cancer Center Partnership, 3/3 Morehouse School of Medicine/Tuskegee University/University of Alabama at Birmingham O'Neal Comprehensive Cancer Center Partnership
OpenAlex ID: W2080413361