Work

The many faces of DNA polymerases: Strategies for mutagenesis and for mutational avoidance

Year: 2000

Type: article

Abstract: Fast, low-cost, accurate detection of time-resolved dynamic nucleic acid conformational variation in response to small molecule binding: 1) enriches our understanding of nucleic acid structure, and regulation of structure by small molecules as ...Nucleic acids can undergo conformational changes upon binding small molecules. These conformational changes can be exploited to develop new therapeutic strategies through control of gene expression or triggering of cellular responses and can also be used ...

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.120152397

Authors: Errol C. Friedberg, William J. Feaver, Valerie L. Gerlach

Institution: The University of Texas Southwestern Medical Center

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2080483936

FWCI: 13.64

Cites: 45

Cited by: 222

Related to: 10