Work

Enantiomerization Dynamics and a Catalytic Dynamic Resolution of N-Trimethylallyl-2-lithiopyrrolidine

Year: 2009

Type: article

Abstract: The barriers to enantiomerization of N-trimethylallyl-2-lithiopyrrolidine have been measured in the presence of sparteine,1, N,N'-diisopropylbispidine, 2, and diaminoalkoxide 3. We have additionally demonstrated a rare example of a catalytic dynamic resolution using either of two ligands, achieving enantiomer ratios of up to 93:7.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja900755a

Authors: Timothy K. Beng, Taher I. Yousaf, Iain Coldham, Robert E. Gawley

Institutions: University of Arkansas at Fayetteville, University of Sheffield

Language: English

Topic: Coordination Chemistry and Organometallics

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: U.S. Public Health Service, National Center for Research Resources

Awards: Center for Protein Structure and Function, G7772536260