Work

Charting the course across the blood-brain barrier

Year: 2010

Type: article

Abstract: The blood-brain barrier (BBB) presents a significant obstacle to delivery of targeted therapies to brain tumors. In this issue of the JCI, Staquicini and colleagues apply an in vivo phage-displayed library of random peptides to identify differentially expressed peptides that can be used to transport targeted agents across the intact BBB. The authors uncover a non-canonical, peptide-mediated iron-mimicry mechanism to induce transport of the transferrin/transferrin receptor complex across the BBB. They then demonstrate the ability of phage-targeting approaches to deliver therapeutic cargo and molecular imaging reporters across the BBB in an intracranial glioblastoma mouse model.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci45758

Authors: David Nathanson, Paul S. Mischel

Institution: University of California, Los Angeles

Language: English

Topic: Barrier Structure and Function Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Ben and Catherine Ivy Foundation, National Institutes of Health, National Cancer Institute, David Geffen School of Medicine, University of California, Los Angeles