Hierarchically Ordered Nanopatterns for Spatial Control of Biomolecules

Year: 2014

Type: article

Abstract: The development and study of a benchtop, high-throughput, and inexpensive fabrication strategy to obtain hierarchical patterns of biomolecules with sub-50 nm resolution is presented. A diblock copolymer of polystyrene-b-poly(ethylene oxide), PS-b-PEO, is synthesized with biotin capping the PEO block and 4-bromostyrene copolymerized within the polystyrene block at 5 wt %. These two handles allow thin films of the block copolymer to be postfunctionalized with biotinylated biomolecules of interest and to obtain micropatterns of nanoscale-ordered films via photolithography. The design of this single polymer further allows access to two distinct superficial nanopatterns (lines and dots), where the PEO cylinders are oriented parallel or perpendicular to the substrate. Moreover, we present a strategy to obtain hierarchical mixed morphologies: a thin-film coating of cylinders both parallel and perpendicular to the substrate can be obtained by tuning the solvent annealing and irradiation conditions.

Source: ACS Nano

DOI: 10.1021/nn505548n

Authors: Helen Tran, Kacey Ronaldson, Nevette A. Bailey, Nathaniel A. Lynd, Kato L. Killops, Gordana Vunjak-Novakovic, Luis M. Campos

Institutions: Columbia University, The University of Texas at Austin, U.S. Army Combat Capabilities Development Command Chemical Biological Center

Language: English

Topic: Block Copolymer Self-Assembly

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: National Science Foundation, U.S. Department of Defense, U.S. Department of Energy, National Institutes of Health, Office of Science, American Chemical Society Petroleum Research Fund, National Defense Science and Engineering Graduate, National Institute of Biomedical Imaging and Bioengineering, Division of Materials Research, Argonne National Laboratory

OpenAlex ID: W2080520817