Work

Direct mass spectrometry analysis of untreated samples of ultralow amounts using extraction nano-electrospray

Year: 2013

Type: article

Abstract: Direct mass spectrometry analysis of untreated samples of volumes as low as 0.2 µL were achieved using fast extraction and nanoESI (electrospray ionization) in a combined fashion. The analytes in dried samples on paper substrates were extracted by organic solvent in a nanoESI tube and ionized with a high voltage applied for generating a spray. The ionization source produced stable signals for different atmospheric pressure interfaces of triple quadrupole instruments. Analysis time more than 20 minutes were available with 10 µL solvent consumed for the entire analysis process. The performance in qualitative and quantitative analysis was characterized with a wide variety of samples. Limits of detection as low as 0.1 ng/mL (corresponding to an absolute amount of 0.05 pg) were obtained for analysis of atrazine in river water, thiabendazole in orange homogenate, and methamphetamine in blood.

Source: Analytical Methods

DOI: 10.1039/c3ay41149d

Authors: Yue Ren, Jiangjiang Liu, Linfan Li, Morgan N. McLuckey, Zheng Ouyang

Institution: Purdue University West Lafayette

Language: English

Topic: Mass Spectrometry Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institute of General Medical Sciences, National Center for Research Resources

Awards: Paper Spray Ionization Mass Spectrometry Device for Direct Analysis of Biofluid S, Paper Spray Ionization Mass Spectrometry Device for Direct Analysis of Biofluid S