Work

NOD‐like receptor (NLR) signaling beyond the inflammasome

Year: 2010

Type: article

Abstract: Recent years have witnessed a marked progress in our knowledge of NOD-like receptors (NLR), intracellular sensors with central roles in innate and adaptive immunity. A majority of the research has focused on caspase-1 inflammasomes. However, several members of the mammalian NLR family exert important roles in immunity beyond inflammasome signaling. Here we highlight the emerging roles of several of these NLR.

Source: European Journal of Immunology

DOI: 10.1002/eji.200940211

Authors: Patrick J. Shaw, Mohamed Lamkanfi, Thirumala‐Devi Kanneganti

Institutions: St. Jude Children's Research Hospital, Ghent University

Language: English

Topic: Inflammasome and immune disorders

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Cancer Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: Role of IL-1alpha signaling in inflammatory diseases and host defense, G216989177, G3789341260, Cancer Center Support Grant (CCSG)