Work

The heat shock protein-CD91 pathway mediates tumor immunosurveillance

Year: 2014

Type: article

Abstract: Tumor immunosurveillance can be readily observed in mice and humans. Here, we examine how T-cell responses are primed during tumorigenesis, a condition in which immunostimulatory antigens are extraordinarily scarce. We recently demonstrated that the HSP-CD91 pathway is indispensable for antigen cross-presentation, and thus immunosurveillance, in cancer.

Source: OncoImmunology

DOI: 10.4161/onci.28222

Authors: Yu Jerry Zhou, Robert Julian Binder

Institution: University of Pittsburgh

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913