Year: 1980
Type: article
Abstract: Response of antidiuretic hormone to chlorpropamideChlorpropamide has been used to treat diabetes insipidus since 1966,1 but its mode of action is still not entirely clear.There is good agree- ment that it augments the renal effects of endogenous antidiuretic hormone,2 but it might also cause pituitary release.3To help clarify this we have measured serial plasma concentrations of antidiuretic hormone in a group of patients receiving long-term chlorpropamide. Patients, methods, and resultsEleven patients with maturity-onset diabetes (two women; age range 38-66 years, mean 56 years) requiring treatment with oral hypoglycaemics were studied.All were receiving conventional dietary advice.Blood was taken from an antecubital vein (after 30 minutes' sitting and overnight fast) before and four, eight, and 12 weeks after they started taking 250 mg chlorpropamide daily.Plasma concentrations of antidiuretic hormone were measured by radioimmunoassay (normal range 4-12 jtg/l).This method is reliable in
Source: BMJ
Authors: R D Jones, J G Jones
Language: English
Subfield: Anesthesiology and Pain Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2081216477