Work

“Control” laboratory rodents are metabolically morbid: Why it matters

Year: 2010

Type: article

Abstract: Failure to recognize that many standard control rats and mice used in biomedical research are sedentary, obese, glucose intolerant, and on a trajectory to premature death may confound data interpretation and outcomes of human studies. Fundamental aspects of cellular physiology, vulnerability to oxidative stress, inflammation, and associated diseases are among the many biological processes affected by dietary energy intake and exercise. Although overfed sedentary rodents may be reasonable models for the study of obesity in humans, treatments shown to be efficacious in these animal models may prove ineffective or exhibit novel side effects in active, normal-weight subjects.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.0912955107

Authors: Bronwen Martin, Sunggoan Ji, Stuart Maudsley, Mark P. Mattson

Institutions: National Institute on Aging, National Institutes of Health

Language: English

Topic: Diet, Metabolism, and Disease

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institutes of Health