Work

Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt / plt mouse

Year: 2000

Type: article

Abstract: The spontaneous mutant mouse strain, plt/plt, lacks the secondary lymphoid organ chemokine (SLC)-ser gene and has disrupted trafficking of T cells and dendritic cells (DCs) to lymphoid tissues. We demonstrate here that the gene for the related chemokine, Epstein-Barr virus-induced molecule-1 ligand chemokine (ELC), is also deleted in this immunodeficient mouse strain. Using a combination of approaches, including bone marrow reconstitution and double in situ hybridization, we show in wild-type mice that ELC is expressed by T zone stromal cells that also make SLC. Smaller amounts of ELC are made by DCs, predominantly of the CD8(+) phenotype. We propose that ELC- and SLC-expressing T zone stromal cells play a central role in bringing naive T cells and DCs together for the initiation of immune responses.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.97.23.12694

Authors: Sanjiv A. Luther, H. Lucy Tang, Paul L. Hyman, Andrew G. Farr, Jason G. Cyster

Institutions: Howard Hughes Medical Institute, University of California, San Francisco, University of Washington

Language: English

Topic: Chemokine receptors and signaling

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green