Work

Diffusive dynamics of the reaction coordinate for protein folding funnels

Year: 1996

Type: article

Abstract: The quantitative description of model protein folding kinetics using a diffusive collective reaction coordinate is examined. Direct folding kinetics, diffusional coefficients and free energy profiles are determined from Monte Carlo simulations of a 27-mer, 3 letter code lattice model, which corresponds roughly to a small helical protein. Analytic folding calculations, using simple diffusive rate theory, agree extremely well with the full simulation results. Folding in this system is best seen as a diffusive, funnel-like process.

Source: The Journal of Chemical Physics

DOI: 10.1063/1.471317

Authors: N. D. Socci, J. N. Onuchic, P. G. Wolynes

Institutions: University of California San Diego, University of Illinois Urbana-Champaign

Language: English

Topic: Protein Structure and Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2081760211

FWCI: 10.13

Cites: 22

Cited by: 502

Related to: 10